POWERMAN
Well-known member
From what I've read, it seems J&J's vaccine is a slightly different in terms of delivery (Adenovirus) vs what Pfizer and Moderna use.
Granted its effectiveness is a bit lower than that of the mRNA based RNA lipid vaccines:
"The Johnson & Johnson vaccine is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, the Johnson & Johnson vaccine uses double-stranded DNA."
So its option 2 or 3 under the "genetically engineer particular virus genes..." flow:
I wonder if this means it is safer in the sense that the tendency for adverse reactions will be a lot less compared to what we see using the single strand RNA lipid now...?
Granted its effectiveness is a bit lower than that of the mRNA based RNA lipid vaccines:
How the Johnson & Johnson Vaccine Works (Published 2022)
An adenovirus helps prime the immune system to fight the coronavirus.
www.nytimes.com
"The Johnson & Johnson vaccine is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, the Johnson & Johnson vaccine uses double-stranded DNA."
So its option 2 or 3 under the "genetically engineer particular virus genes..." flow:
I wonder if this means it is safer in the sense that the tendency for adverse reactions will be a lot less compared to what we see using the single strand RNA lipid now...?