Lots. The first company I worked for was founded and led by a fellow who left school at grade 10, drove a coffee truck for 10 years, then recruited the smartest folks he could find to startup a tech company. Including me.
He led the company from 0 to $20m in 5 years, developed pc networking and pc fax products that revolutionized communications, employed 100+ people.
The company I work for now was started by a travelling salesman (no degree), holds several patents, and is the biggest in Canada today. Not a single member of our exec team has a degree.
Small sample, but Gates, Zuckerberg, Ellison, Jobs, Branson, Dell, Allen, Dorsey, Turner, Edison, Disney, Murdoch, Winfrey, Rockefeller, Rhianna and Swift come to mind as people that have driven technology or civic advancements.
Trudeau has a degree.