It's actually fairly well known what the differences are between the production H2 and H2R. The important ones are: Rev limit (14,000 vs 13,000), cam timing (substantial), the R has a lower compression ratio achieved by a higher deck height on the block (cylinder head and pistons are the same), ECU tuning, tires (DOT vs slicks). The bodywork is different despite looking similar. The R has the air filter up front where the street one's headlight housing is, and the street one has the air filter at the supercharger inlet, but despite this, the street one's intake configuration is not restrictive and this is not a limiting factor.
What the aftermarket has figured out, is how to build an intercooler into the stock (pressurized) airbox. That has allowed regearing the supercharger to spin it faster for more boost without melting down (most of the time).
I know of someone local who had one that was tuned and intercooled, and blew it up, but it was a connecting rod that let go, not a piston meltdown (which happened a few times before the intercooling got figured out). That bike had a hard life, with lots of dragstrip and top speed runs. It has been rebuilt, now with Carillo rods and who knows what else. Same shop rebuilt that one, which built the one in the video above ...