Yes, that's one of the big ones. Until that gets sorted I would suggest no one get married. This mostly applies to guys. But this thought experiment is about how long to wait to have real physical intimacy with one you hope to spend the rest of your life with. There is some strong evidence to suggest a rethink.
There is some strong internal chemical persuasion limiting my likelihood of running such an experiment... not to mention the ol "only enough blood to run one head at a time"