I guess it really depends on the time & direction of your travel.
I work in Markham, and when I need to head downtown after work, I take the DVP. Getting onto the DVP from the 400 is tricky at times, but being on a bike, your lane change options are greatly increased, so the wait isn't usually too bad. Once you're past Don Mills, it flows nicely all the way to the Gardiner.
When I'm on my bike, I can usually navigate traffic a LOT better than in my car... making aggressive moves in a car make other drivers mad, but the same ones on a bike; not so much.(I find). I guess it's because cagers can always see past you when on a bike.