Mad Mike
Well-known member
Doubles as a top box when she’s not with you.For off road use only.
Just get a bike big enough for her and the potti.
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Stay at Home Order - Spring Edition
- Thread starter justride
- Start date
Not a good spot for your groceries.
For off road use only.
Just get a bike big enough for her and the potti.
Might be good against tailgaters, just have to rig a quick release drain.
Except my toilet paper hoard.
Read it again. Both Pfizer and Modena say the second shot needs to be administered between 21-28 days after the first to be effective. Our head a'hole has decided we can wait 4 months for the second shot. I'd bet the farm Trudy's already gotten both of his doses before the end of February.
Ok. Still, what choice do you have? Unless you go with Pfgmgd's idea of booking at multiple pharmacies three weeks apart but then you are probably getting AZ. I'm not saying what they are doing is right, but they have decided on a path and we are pretty much along for the ride.
Narcity is trash written by amateur “journalists”.
its been on instagram feeds allllll day over and over. people are reposting it like crazy.
at first i thought they were laughing at it, then i read the comments
That isn't quite what is meant. The 21 - 28 days is the timing that was tested during their phase 3 trials. They did not test other timings in an attempt to find any sort of "optimum". THIS DOES NOT MEAN IT WON'T WORK. In fact, it does not even mean it is the "best" or "optimum" timing.
There is nothing magic about 21 or 28 days. That timing was a (hopefully educated) guess by the vaccine developers which was a compromise between "establishing some sort of reasonable delay between doses", and "minimise the overall length of the phase 3 trial so that we can get this vaccine approved and out there in use".
"Why didn't they test other timings to find what's best" - Because it would extend the duration of the phase 3 trial and multiply the number of participants by the number of different other timings that you want to try. Unofficially, it WAS tested during the phase 3 trial ... by trial participants whose lives got in the way of getting their second dose exactly at the prescribed time.
My understanding is that vaccines in general, when a two-shot strategy is used, the delay is commonly 3 - 6 months.
And it is entirely possible that the best timing between shots for someone 80 years old is different from what's best for someone 30 years old and may be different for someone immunocompromised. Those tests haven't been done.
Delaying this vaccine for another year while doing all that testing ... was not in the public interest. "Get the testing done ... get it out there" is the way it had to be.
The UK has only administered a relatively small number of second doses at all. Their real world outcome has been very good. And half of their doses have been with the much-maligned AstraZeneca vaccine.
On a related note, I just booked my first jab with Trillium Health Services, as they were taking appointments for over-50's in prescribed postal regions (and I'm in one of them) in advance of the provincial booking system starting to do the same tomorrow. The second dose is to be 16 weeks later. I'm not concerned. The important thing is that this will put the second one in mid-August so that it will be fully kicked in by September when I still have a European vacation in the plans ...
None, and that's not the point. I'm sick and tired of getting lied to by these *****. From Trudy telling us all to stay home at Easter during the first stay at home order then going out of province himself, to the ***** posting fake Twitter posts from "home" when they were in the Caribbean while we were on the xmas lockdown, to the ***** telling us we have to be vigilant and wait for vaccines when we KNOW they've all taken care of themselves and their circle. Now the manipulated footage cherrypicked from always busy Toronto ICUs. I've had it. They can tell me the sky is falling now and I won't bother to look out the window to check if it is.
Phase 3 trials were last quarter 2020. As of March, with another 4-5 months of real world data, Pfizer, Modena, and the CDA are all standing by their 2nd dose recommendations. My understanding from what I've read is the first shot gets your body to start producing the protein spike mimicking agent (don't know the scientific terms). The second is to reinforce the first (terms, again), and as the first shot's efficacy lessens over time the second shot isn't as effective as it should be.
"The U.S. Centers for Disease Control and Prevention (CDC) says, as of Mar. 3, that: “The second dose of Pfizer-BioNTech and Moderna vaccines should be administered as close to the recommended interval as possible … (i.e. 3 weeks for Pfizer-BioNTech, or 1 month for Moderna) … (If) a delay in vaccination is unavoidable, the second dose of Pfizer-BioNTech and Moderna COVID-19 vaccines may be administered up to 6 weeks (42 days) after the first dose. Currently, only limited data are available on efficacy of mRNA COVID-19 vaccines administered beyond this window.”
Our Squalking Heads (parrots?) are all saying now that we can make do with 14 weeks. Do you believe them? I don't. The tell is the last sentence in the statement. Reads: "we have some data, and from what we've seen so far, we're not even going to say that it may be effective".
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Mad Mike
Well-known member
Here’s how the Dr who jabbed me explained it. Dose 1 gets you started and wiill after a few days be working to keep you safe. It’s not going to last forever, a perfect situation is the next dose in a couple of weeks. The second jab is necessary, if you get it in 2-3 weeks you won’t likely get the Vid. The good part is if you dont get 2nd shot for 6mo you can get the Vid, but you won’t get very sick and you won’t die.
Supply is the issue. By delaying shot 2, more can get shot 1 which prevents a fatal outcome. Some will get a mild case of the Vid, fewer get really sick, fewer die.
I’m ok with that.
Mad Mike
Well-known member
I don’t think the bypassed science, Trudeau is held responsible for supply - he simply shi+ His bed.
The USA would have been my first bet for supply, as much as a Shittshow it was last year, they usually end up winners. And they honour commitments. We refused to buy doses from Americans.
Our buddy cozied up to euro friends who simply took Canada’s prepayment for 400,000,000 doses and laughed at the dummy.
Four months has never been tried. "DOESN'T MEAN IT WON'T WORK" doesn't cut it in science.
You make your hypothesis. Test it. Draw the conclusions. Then apply it in the real world.
Mixing up the order bypasses the science. Eventually, we should know if four months is good for old people, unless it's really, really bad for them.
The weird part is that up until a certain point in time, everyone, young and old were getting the shots at the recommended times.
Relax
Well-known member
I had the scientific method beaten into me all throughout high school and university. The vaccines' efficacy and safety were approved based on a set of conditions during the trials. If you change those conditions, you're no longer "guaranteed" the same results. Delaying the second dose can impact efficay in three ways - it can make no difference, it can increase, or it can decrease. My problem is if it decreases, how much will it be by, and at that point, is it better to just not have it at all so that everyone else can get a first shot?
Well if you are leaning on science, 100% of the unvaccinated are a problem. They are a vector for spreading and they have a chance of ending up in hospital. After a single shot, hospital visits are out of the picture and many people lose the ability to be a vector. Although saving individuals is good, the bigger problem for humanity is we have to stop the rapid replication. One of the inevitable variants is going to be very bad for us if we give the virus billions of chances to mutate and find a more effective strain.
Thing is, we don't quite know how long that lasts with just a single shot for most vaccines.
Also, don't forget, that vaccinated people have caught covid, and we don't really have data on whether they can spread it.
Catching covid with the vaccine, might create a superior resistant variety.
We've branched off into speculation, and keep changing plans, as our ideas, and nightmares become wilder. A chaotic plan is sometimes worse than no plan, and is always worse than a mediocre, but well executed one.
Trump was in power at the time. It would have been anticipated that the USA would hoard all internal production for themselves ... and they have.
The EU respects agreements. And they have been doing so.
If Canada had sourced all vaccine from the USA, we would have had exactly zero vaccinations thus far.
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