Shane we know you can do the distance but you do need the smell the roses and you certainly cannot do long distance on 101 down the west coast tho October is very nice.
Going across you want to hit Chief Joseph, Beartooth Pass and Yellowstone. ...maybe the Badlands. I'd not do that Michigan ferry. Just get by Chicago off hours or do the MicMac bridge and blitz the National Forest west.
goo.gl
On the way south you can pick up Mount St. Helens and then cut to the coast along 101 .. ( you could loop around Mt Ranier if you have time. )
goo.gl
Then cut across to 101 ...but check the weather ....Astoria and south could be fogged in big time and it's no fun.
But put this in the route map.
Pelican Brewing: Born at the Beach | Pelican Brewing Co
Fantastic place - good food....nice break not far off 101. Incredible setting.
more here
Pacific Coast
Then Aim for Fort Bragg north of San Fran and stay on the coast on Hwy 1 instead of 101.
this is a worthwhile stop in San Fran
The California Academy of Sciences is a science museum—and scientific and educational institution—located in San Francisco's Golden Gate Park.
www.calacademy.org
Whet your appetite
500px.com
500px.com
Have your wife fly back from San Fran instead of LAX.
Monterey, Big Sur and Pebble Beach are worth the ride along the coast.
I see no point in going further south than San Luis Obispo.
Cut over to Yosemite, try and pick up Sequoia National Park. The road down going east is wild.
You want to buy a season pass for the parks.
US Park Pass | National Park Entrance Pass It's $80 - most parks are $25 so pays for itself quickly and good for a whole year.
Head over to Utah Bryce, Arches, etc in Utah....this is a must see Shane
Southern Utah is a cumulation of beautiful and unique national park destinations, national monuments and state parks which each provide a unique and unforgettable experience.
www.nationalparkreservations.com
Colorado I don't know but worth it. Maybe the Ozarks and Smokies and home.
My 2C