DR650 is like halfway between the 400 and Vstrom. Are you getting ride of one of those? I think 400 and Vstrom is a pretty good combo.
Eventually I might get rid of both bikes and replace them with a DR650... but not just yet -- I'm thinking of another season or two with this pair before I move on.
Part of the reason is paying double insurance, double the maintenance, and taking double my garage space. I also like the inherent simplicity of the DR650... for one example, valve checks are required more often, but they are screw adjustable valves that supposedly take a total of 20 minutes to check and adjust. The Vstrom, on the other hand, needs most of the bike disassembled for a valve adjustment -- on one side of the V the rad, tank, air box, and possible throttle body needs to come off, and that is the simple side. The other side people have talked about removing the swing arm. I just had a valve check done on the Vstrom, and it is within spec, but I might sell it and get my value out of it before the next valve check/adjustment. The DR is also air-cooled with an oil cooler, analogue speedo/odo, just plain simple all around... my kind of bike, very little to break, just dead reliable. Not that the Vstrom isn't reliable, but it certainly has a lot more that can go wrong (ABS, EFI, etc).
The DR650 is similar to the DRZ, so no reason to have both of them. I've read that the DR is much more comfortable on the longer rides and feels less like riding on a 'twitchy rail' as some describe the DRZ. I like my DRZ... but if I am going to go with only one bike, I would replace it. The DRZ also has a weak subframe so can't take much luggage, so it can't be made into much of a touring beast.... the DR can be.
Finally, nearly every time I ride I am usually at least on gravel and looking for trails/non maintained roads. I have tried, but don't have a lot if interest in pavement only trips seeking out twisties... I much prefer running gravel roads with almost no vehicles than running down to the dragon (which I've done). In the past three seasons I've done multiple trips to Pennsylvania, New York, and Vermont, did the Trans-lab, did the James Bay run, did the Devil's Whip, Blue Ridge Mountains, etc, etc, etc... 48000km of touring but now prefer puttering along on the gravel roads and staying away from cities and freeways.