DownUnder
Well-known member
Asbestos and Lead didn't kill people instantly. We are not going to know what the long term effects of an mRNA are for a while I think.
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Elephant in the Covid room
- Thread starter Wingboy
- Start date
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BigEvilDoer
Well-known member
I work for CP.
They haven't helped get any employees get a shot.
Got mine on my own with a bunch of luck.
Yes that’s true. We didn't have the time to wait for that though and we do have significant scientific resources to make very accurate predictions.
Using your example though all drugs would have to wait 10-15 years before they are finally sold before you’re sure. So in this case, that’s 10-15 years of continuous infections, with multiple variants and all the associated issues with that.
I think he was being facetious as the stories of the retirement party (attended by management) shutting down a shift at the sorting plant due to an outbreak made CP look pretty crap.
BigEvilDoer
Well-known member
Fair enough.
We've had to go through a whole bunch of hoops since the first shutdown of the Gateway processing plant in Mississauga.
Serious pain in the butt on a daily basis.
Or it becomes the next mesothelioma and we all get to see 4 ads an hour on TV to get our free handbook.
An opinion based on simple mathematics, no interpretation required, published in one of the oldest most respected medical journals.
I'll take that over an opinion of someone online, who cries woe over trial costs, while Pharmaceutical companies as a whole manage to outperform the rest of the market in earnings as a percentage of revenue.
Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies
How do the profits of large pharmaceutical companies compare with those of other companies from the S&P 500 Index?In this cross-sectional study that compared the profits of 35 large pharmaceutical companies with those of 357 large, nonpharmaceutical ...
www.ncbi.nlm.nih.gov
Forgive me if I don't care that the difference means one less private jet, or kickback being paid out to a doctor or researcher. If it means past mistakes with trials are less likely to go through.
Or it becomes the next mesothelioma and we all get to see 4 ads an hour on TV to get our free handbook.
An opinion based on simple mathematics, no interpretation required, published in one of the oldest most respected medical journals.
I'll take that over an opinion of someone online, who cries woe over trial costs, while Pharmaceutical companies as a whole manage to outperform the rest of the market in earnings as a percentage of revenue.
Profitability of Large Pharmaceutical Companies Compared With Other Large Public Companies
How do the profits of large pharmaceutical companies compare with those of other companies from the S&P 500 Index?In this cross-sectional study that compared the profits of 35 large pharmaceutical companies with those of 357 large, nonpharmaceutical ...
Forgive me if I don't care that the difference means one less private jet, or kickback being paid out to a doctor or researcher. If it means past mistakes with trials are less likely to go through.
Opinions are not peer reviewed...they are just opinions. There are many more from very experienced and highly regarded scientists that say you should get vaccinated with whichever vaccine is available. Their opinions are backed up with the very observable and measurable evidence of countries getting back to normal the more their population is vaccinated.
So..you choosing one opinion over demonstrable facts is your bias.
That is very true. Hard numbers are not opinions, anymore then saying the sky is blue. Which is what makes the BMJ article less opinion, and simple fact that Pfizer hid data from their public facing study.
Like they have hid their manufacturing problems.
The EMA covid-19 data leak, and what it tells us about mRNA instability
Leaked documents show that some early commercial batches of Pfizer-BioNTech’s covid-19 vaccine had lower than expected levels of intact mRNA, prompting wider questions about how to assess this novel vaccine platform, writes Serena Tinari As it conducted its analysis of the Pfizer-BioNTech...
You clearly have a working bias, to Pfizer or perhaps the whole industry. Willing to shill for them, and ignore things that don't suit your narrative of unrestricted access to sell drugs and let problems be damned.
Anyway, good luck with that.
That is very true. Hard numbers are not opinions, anymore then saying the sky is blue. Which is what makes the BMJ article less opinion, and simple fact that Pfizer hid data from their public facing study.
Like they have hid their manufacturing problems.
The EMA covid-19 data leak, and what it tells us about mRNA instability
Leaked documents show that some early commercial batches of Pfizer-BioNTech’s covid-19 vaccine had lower than expected levels of intact mRNA, prompting wider questions about how to assess this novel vaccine platform, writes Serena Tinari As it conducted its analysis of the Pfizer-BioNTech...www.bmj.com
You clearly have a working bias, to Pfizer or perhaps the whole industry. Willing to shill for them, and ignore things that don't suit your narrative of unrestricted access to sell drugs and let problems be damned.
Anyway, good luck with that.
Nope...but on my side there’s millions of citizens around the world vaccinated, countless ongoing clinical trials and observations, demonstrated science, normality returning, infection and death rates reducing, ICUs emptying, adverse events in any large numbers NOT present, all during arguably the most visible and monitored rollout of a vaccine in our entire history.
You have one blog.
Good luck with that.
Not sure if this has been posted here before. It’s a good read. This is likely one of the worlds pre-eminent peer reviewed journals
www.nature.com
In short..mRNA tech has been around since 2011 and has been tested in humans since then. There haven’t been any real adverse effects in those trials but what stopped the tech from being widely used were delivery issues. The active component required to elicit the immune response degraded too quickly to do its job. Encapsulation and other technological advances in delivery stopped this problem.
Note the date.
mRNA vaccines — a new era in vaccinology - Nature Reviews Drug Discovery
mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability and delivery issues. Here, Pardi and colleagues discuss recent advances in mRNA vaccine technology, assess mRNA vaccines currently in development for cancer...
www.nature.com
In short..mRNA tech has been around since 2011 and has been tested in humans since then. There haven’t been any real adverse effects in those trials but what stopped the tech from being widely used were delivery issues. The active component required to elicit the immune response degraded too quickly to do its job. Encapsulation and other technological advances in delivery stopped this problem.
Note the date.
DownUnder
Well-known member
It doesn't look like any normality is returning for a very very long time, even with 40%+ of the population vaccinated already. There is talk the current lock down will be extended and talk of a "4th" wave incomming... every passing day the 2 week hotel quarantine in Australia is looking better and better to me considering the quality of life there afterwards, even with less then 10% of the population vaccinated
Haven't you listened to the moron in chief and his minions? We have the toughest border controls in the world.
They must have been working for a week or two a while ago, as the refugee rights lawyers started a lawsuit:
Canada sued for rejecting asylum seekers at U.S. border, officials blame pandemic
You're right...but we (general we...maybe not India) are approaching normality slowly...mainly as a exult of vaccination! Some countries are approaching it faster.
They turned away 387 people in a year and a single one was deported from the US? wtf. Some people need to get a life and stop wasting the courts time with such stupid lawsuits.
mRNA vaccines — a new era in vaccinology - Nature Reviews Drug Discovery
mRNA vaccines represent a promising alternative to conventional vaccine approaches, but their application has been hampered by instability and delivery issues. Here, Pardi and colleagues discuss recent advances in mRNA vaccine technology, assess mRNA vaccines currently in development for cancer...
Great article pushing for an obscure technology... Let's see who wrote it shall we?
The patent filings list...
One step further ...
Main - Acuitas
acuitastx.com
Which goes back full circle with some of their other research and articles...
Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques - PubMed
Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation of more effective anti-HIV vaccines is critically needed. Here we characterize the immune responses induced by...
pubmed.ncbi.nlm.nih.gov
Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes - PubMed
In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types and tissues needs to be achieved. Lipid nanoparticles (LNPs) are efficient carriers for short-interfering RNAs and...
pubmed.ncbi.nlm.nih.gov
Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination - PubMed
Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. There are no ZIKV-specific treatments or preventatives. Therefore, the development of a safe and effective vaccine is a high priority. Messenger RNA (mRNA) has emerged as a...
pubmed.ncbi.nlm.nih.gov
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge - PubMed
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development and manufacturing. Here we present a safe and cost-effective platform for in vivo expression of therapeutic antibodies using...
pubmed.ncbi.nlm.nih.gov
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses - PubMed
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in...
pubmed.ncbi.nlm.nih.gov
Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response - PubMed
T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects of constitutively active T cells. Previous studies have shown that mRNA CAR T cells are transiently effective but lack...
pubmed.ncbi.nlm.nih.gov
All these studies with these authors were for Acuitas and/or BioNTech and had their employees on hand. I'd post more but every other study on NIH listed them so after 6 of 12 the pattern is well enough established.
But absolutely no conflict of interest here... None what so ever. ?
Great article pushing for an obscure technology... Let's see who wrote it shall we?
The patent filings list...
One step further ...
Main - Acuitas
Which goes back full circle with some of their other research and articles...
Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques - PubMed
Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation of more effective anti-HIV vaccines is critically needed. Here we characterize the immune responses induced by...Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes - PubMed
In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types and tissues needs to be achieved. Lipid nanoparticles (LNPs) are efficient carriers for short-interfering RNAs and...Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination - PubMed
Zika virus (ZIKV) has recently emerged as a pandemic associated with severe neuropathology in newborns and adults. There are no ZIKV-specific treatments or preventatives. Therefore, the development of a safe and effective vaccine is a high priority. Messenger RNA (mRNA) has emerged as a...Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge - PubMed
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development and manufacturing. Here we present a safe and cost-effective platform for in vivo expression of therapeutic antibodies using...Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses - PubMed
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this study, we characterize a recently developed vaccine platform, nucleoside-modified, purified mRNA encapsulated in...Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response - PubMed
T cells made with messenger RNA (mRNA) encoding chimeric antigen receptor (CAR) offer a safe alternative to those transduced with viral CARs by mitigating the side effects of constitutively active T cells. Previous studies have shown that mRNA CAR T cells are transiently effective but lack...
All these studies with these authors were for Acuitas and/or BioNTech and had their employees on hand. I'd post more but every other study on NIH listed them so after 6 of 12 the pattern is well enough established.
But absolutely no conflict of interest here... None what so ever. ?
Err...they are describing a technology in one of the world's pre-eminent journals. It's 2018...no COVID on the horizon. You don’t seem to understand how science works?
That might be the biggest elephant in the covid room. On social media, no one, nada, nobody, not me, not you seem to understand how science works. Different priorities keep getting in the way.
science works by presenting provable evidence. What happens after that veers off into politics etc.
Social media is just a bunch of people yapping (like here). Science is still science and no place for anti-vaxers.
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