If the price is right, don't sweat the mileage...metrics go forever, especially a Honda. There are VTX's out there with 200,000km on them and still going with no issues.
Look at it from this perspective - would you consider a Honda, Toyota, or Subaru (also all Japanese made/designed cars) with 100,000km "end of life"? Most metric motorcycles are built the same.
I just bought my current ride with 50,000km on it and that's fine. I expect to ride the wheels off the thing and will likely be over 150,000km inside 5 years, and expect to own it until it's north of 200,000km.
Again, the price must reflect the mileage, but if you find a $2000 totally farkled out VTX with 100,000km on it, vs a $4000 one with 25,000km, I wouldn't discount the 100,000km one whatsoever.
There's a strong argument to be made that a bike that was ridden regularly and with highway miles has had a much easier life than one that was started, rode 10km to the nearest Tim Hortons parking lot and then revbombed all day to make noise, before being ridden 10km home again, repeat all summer. Short trips are far harder on an engine than long ones.