We took Interstate all the Way. We were a group of 15 and this made perfect sense for us. We reached Robbinsville, NC on the second day.
Day 1....We loved I79 and 19. They were scenic, curvy and fast. All these stops are Gas Stations with good choice for food. Some of us stopped on each stop, others on alternative stops. We covered 900kms in about 12 hours. I79/19 are like 118 in Ontario but four lanes and faster traffic. Our night stop was in Beckley WV.
Day2
Our Day 2 was from Beckley, WV to Robbinsville, NC. We covered Back of the Dragon and Devil's Whip, but for travelling I stuck to Interstate. Again, it was a wonderful day and we reached Two Wheels Inn, NC as per our schedule.
If you are comfortable on Interstate, then do that as it will give you everything you want....Speed, Scenic, Curves and Time saving. 219 is very nice road but 1 Law Abiding Driver can add hours to your day. We traveled to Robbinsville, NC on Friday of the Memorial day Weekend, not even once we hit any traffic. You will find many back roads near TOD, which are very good. We stuck to Interstate to reach in time, but in no way we were prepared for such amazing highways. We had a Blast.
We took the same route back with some changes.