I have a 2007 diesel F350 single rear wheel as my non-motorcycle transportation. If I had to drive the truck as a daily commuter, it would be seriously impractical. Luckily, because I live in California, I ride my motorcycle to work almost every day.
Some practical considerations if you are seriously considering a 3/4 or 1-ton pickup (the 3/4 and 1-ton single rear wheel trucks are identical except for usually suspension components - stiffer springs, more leafs in the pack, etc.):
-The truck gets terrible mileage in the city (about 23-25L/100km), but semi-decent mileage on the highway for a big truck (13-14L/100km).
-It's a crew cab (but thankfully a short bed), so the wheelbase is about 13 feet - total length is around 21 feet.
-Handling-wise, it has solid front and rear axles, so it rides like a tank, especially when you aren't carrying anything in the bed.
-For maintenance, an oil+filter change requires about 15L of oil. My truck is old enough not to require DEF, but there are fuel filters you need to change regularly.
-Any serious work that needs to be done is labor intensive and therefore expensive - for my vintage truck, one Ford tech told me that sometimes they will remove the entire truck cab to make the repair easier.
-Parking is awkward - the truck won't fit into a stall unless other people park properly (mirror to mirror is approximately 9 feet wide) and I can't make a u-turn on a city street unless the road has at least 3 additional lanes (ie: in order to make a u-turn from the left turn lane, the oncoming traffic road would need to be at least 3 lanes wide). Anything narrower results in a 3 point turn.
-The truck weighs almost 8000 lbs with fluids and me as the driver - a lot of parking structures have weight limits
-The truck is 81" (almost 7 feet) tall which also prevents you from entering many parking structures. I've come within an inch or two of the roof in a few parking structures
-The bottom of the side windows is above the roof-line of many cars. When you change lanes, you have to make sure you angle your mirrors down to check for any cars below the door line (especially on the passenger side). When I first got the truck, I almost lane changed into cars that were driving next to me because I didn't have the mirrors adjusted properly.
The main reason I have this truck is because I have a large truck camper. As much as I love my truck, I would be hard pressed to justify the cost and expense of owning it without the camper. If you don't need the tow/hauling capacity of a 3/4 or 1-ton truck, I don't recommend it as a daily driver.
EDIT: Oh, also, don't crash into anyone else. They will almost certainly be killed.
[video=youtube;pLzYLlCmNcE]http://www.youtube.com/watch?v=pLzYLlCmNcE[/video]