Hubby has watched several how to videos, however not getting a straight answer...should the radiatorbe full while the bike is running or off?...
The engine should never be running with an empty (as in "DRY") cooling system.
Identify the radiator cap, the coolant reservoir cap, the drain point of the cooling system (either a dedicated drain screw, or the lowermost coolant hose), and the drain point of the coolant reservoir (usually this will involve the little hose at the bottom of it).
Put a drain pan underneath the bike. Engine cold.
Remove the radiator cap.
Remove drain screw (if provided) or undo lowermost coolant hose clamp and pull hose off nipple (if there is no designated drain screw) and drain the coolant into the drain pan.
Remove the hose connecting to the bottom of the coolant reservoir, and drain that into the drain pan as well.
Sometimes, for purposes of getting as much out as possible, it helps to tilt the bike to the left as much as you dare and then to the right as much as you dare, a couple of times.
When done draining, pour the drained coolant into a suitable container for recycling, and to ensure that any coolant is not going to attract pets or animals.
Put the drain screw / lower coolant hose back in place.
Fill the cooling system with plain water at the radiator cap. Don't fill the coolant reservoir bottle yet.
Start the engine and note the water level below the radiator cap. It will probably go down due to air pockets being driven out. Top it up as this happens.
After the engine has run for a couple of minutes, stop it, and drain the cooling system again.
For purposes of a normal flush-and-fill, any minor remaining amount of the old coolant is insignificant. For racetrack use, where any trace of green coolant could be grounds for a tech-inspection fail, do this a couple more times until what drains out is clear.
After draining the water the last time, install and torque drain screw / install and tighten coolant hose, and install the drain hose for the coolant reservoir.
Fill mixture of 50% coolant / 50% water through the radiator cap until that's full, and fill the reservoir to the "cold" (lower level) line.
The minor extra amount of dilution from the water remaining in low pockets from the previous operations will ordinarily be of no consequence.
Start the engine and run it while topping up at the radiator cap as it purges air pockets.
Re-install the radiator cap, and stop the engine.
Tilt the bike to left and right as much as you dare a couple of times to encourage air pockets to migrate to the top.
Check and top up the coolant under the radiator cap.
Ride. After the first ride, check the level in the reservoir, and set it to the "low" line. It is entirely normal for air pockets to get purged out over the first couple of warm-up cycles, thus needing topping-up.
There are some *cough* Triumph bikes in which the manufacturer did not see fit to install the radiator cap at the high point in the cooling system, thus leading to a trapped air pocket when the bike is on the side stand. If you have one of those, check the level in the radiator with the radiator cap off with the bike tipped to the other side so that the radiator cap is at the highest spot, and you'll have to put the radiator cap back on with the bike in that position to avoid coolant spilling out.