^ We have to repeat this for the benefit of those who don't know: DOT 5 is absolutely incompatible with DOT 3, DOT 4, and (confusingly) DOT 5.1, whereas the latter bunch are all compatible with each other but have different performance/temperature ratings.
If you mix a DOT 5 brake fluid with anything else, it will gel up and do a lot of damage! If you want to switch a DOT 3/4/5.1 based brake system to DOT 5, you have to completely disassemble the system and clean it thoroughly with alcohol and dry it out - and then you can't switch back. If the vehicle has ABS, it will generally be impossible to completely bleed the DOT 3/4/5.1 out of the system.
The major difference is that DOT 3/4/5.1 are designed to be hygroscopic - they absorb water - and they turn brownish in the process, giving a visual indication of their condition. Water in a brake system is bad news - it promotes corrosion, and if it gets into a brake caliper, it can boil and reduce brake effectiveness at the worst possible time - when the brakes are being used hard. The bad thing about DOT 3/4/5.1 is that if they leak, they eat paint.
DOT 5 is silicone based. It does not damage paint and it is not hygroscopic. But it is more compressible than the DOT 3/4/5.1 family.
I believe Harley-Davidson uses DOT 5 brake fluid. I do not know if they do that on all models. Practically all other vehicle manufacturers use DOT 3 or DOT 4. I've never seen DOT 5.1 in real life.